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A deadly cat-and-mouse game between a world-renowned surgeon and a rogue FBI agent begins in Season 1 of this high-octane suspense thriller. Dr. Ellen Sanders (Toni Collette), a respected Washington, D.C., surgeon is selected to operate on U.S. president Paul Kincaid (James Naughton). But the day before the surgery armed intruders, led by FBI agent Duncan Carlisle (Dylan McDermott), take her family hostage and demand that she kill Kincaid during surgery or they will murder her husband, son and daughter. To buy some time, Ellen slips the president some blood thinner which causes the procedure to be postponed for two weeks. As Duncan and his gun-toting allies hold the Sanders family hostage until the assassination can take place, dark secrets begin to spill out and it becomes clear that Duncan is taking orders from someone higher up and that the conspiracy is much bigger than anyone could imagine.